Treatment with Luteinizing Hormone-Releasing Hormone Antagonists: is Serum Testosterone Reduction the Only Mechanism?
نویسندگان
چکیده
منابع مشابه
Luteinizing hormone-releasing hormone antagonists.
BACKGROUND Luteinizing hormone-releasing hormone (LH-RH) plays a central role in the vertebrate reproduction by regulating gonadal activity. Based on its binding to pituitary LH-RH receptors, as well as to LH-RH receptors expressed on cancer cells, LH-RH agonists and antagonists have been developed for different therapeutic applications. OBJECTIVE/METHOD Here we give an overview of the most r...
متن کاملTreatment with Luteinizing Hormone-ReleasingHormone Antagonists: is Serum TestosteroneReduction the Only Mechanism?
Background: Androgen deprivation therapy (ADT) by surgical or medical castration is recommended for advanced or metastatic prostate cancer. Recent literature suggests that medical castration by luteinizing hormone receptor hormone (LHRH) antagonists might have advantages over treatment with LHRH agonists in patients with metastatic prostate cancer when prostate specific antigen (PSA) progressio...
متن کاملGonadotropin releasing hormone-induced change in serum luteinizing hormone, testosterone and androstenedione in bulls, steers and steers given testosterone.
Two experiments were conducted to determine the effect of gonadal hormones on LH release by successive injections of Gonadotropin Releasing Hormone (GnRH). In the first experiment 1 month-old Holstein bulls were used. Bulls were assigned to be: 1) left intact (n=5), 2) castrated (n=6), or 3) castrated and given 10 mg testosterone thrice daily for 15 days (n=4). All animals received three intram...
متن کاملHuman malignant melanomas express receptors for luteinizing hormone releasing hormone allowing targeted therapy with cytotoxic luteinizing hormone releasing hormone analogue.
Cytotoxic analogue of luteinizing hormone releasing hormone (LHRH), AN-207, binds with high affinity to LHRH receptors and can be targeted to tumors expressing these receptors. We investigated the expression of LHRH receptors in surgical specimens of human malignant melanoma and evaluated the effects of AN-207 in models of human melanoma. Human melanoma specimens derived from primary tumors or ...
متن کاملThe relationship between serum hormone levels (follicle-stimulating hormone, luteinizing hormone, total testosterone) and semen parameters.
OBJECTIVE The aim of this study was to investigate the effect of serum gonadotropin and total testosterone levels on semen parameters. MATERIALS AND METHODS Three hundred and eighty-two patients that applied to a male infertility polyclinic were included in our study. Serum gonadotropin and total testosterone levels and semen parameters of the patients were analyzed during the first visit to ...
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ژورنال
عنوان ژورنال: Journal of Drug Research and Development
سال: 2016
ISSN: 2470-1009
DOI: 10.16966/2470-1009.117